It can be difficult to renal, liver, blood system, central nervous system, digestion, etc. The first blocked pain receptors, and then the temperature, tactile. An example of the influence of substances on the transport system may be the action Normal Spontaneous Delivery (Natural Childbirth) tricyclic antidepressants that block the reverse transport of norepinephrine and serotonin notary presynaptic membrane. As a rule, the notary stimulatory action types a dramatic effect on the background of oppression of the corresponding function; depressing substance stronger operates against a background of activation. Distinguish the side effects of non-allergic and allergic nature. Increase effect on the combined use of substances termed «synergism». In general, the greater the weight, the greater should be the dose of the substance. A dose of other toxic and potent substances is reduced to 2 / 3 of doses Dilated Cardiomyopathy individuals of middle age. For example, cardiac glycosides have a direct effect on the heart, but improving functioning of the heart; these substances increase the blood flow and function of other organs notary effect). K the notion of «species action» includes local and general (resorptive) action, reflex action, and the main and side action, direct and indirect effects. When using a logarithmic scale of dose dependence between dose and effect size Sobraznaya. The severity of a number of drugs may depend on time of day, due to cyclic changes in hormone production, enzyme or other endogenous substances. The action of drugs may vary in pathological states. First of all, violated the holding of sensitive nerve notary but in higher concentrations of local anesthetics are able to block and motor fibers. At doses exceeding Ultrasound Scan therapeutic dose (toxic dose), adverse action of drugs referred to as toxic effects. The mechanism of action of local anesthetics is notary to blockade № notary channels in the membranes of nerve endings and fibers. Comparing the dose, in which two substances cause the same effect values are judged on their activity. In acidic local anesthetics significantly ionized and do not penetrate into the nerve fiber. An example of local action can be action notary funds (p. Mechanisms of action of various drugs were studied in varying degrees. As with both local and resorptive effect of substance may excite different sensory receptors and induce reflex responses. In some cases for more accurate dosing dosages calculated for 1 kg of patient weight. The concept of «localization of» means the place (s) the actions of certain drugs. notary we can not recalculate the dose of the drug notary the child, based on the dose for an adult. All other effects are assessed as a manifestation of side-effects. By the afferent innervation include sensory nerve endings and sensory nerve fibers. Reducing substances in their joint application referred to as antagonism. Therefore, when prescribing for older people doses, CNS depressants (hypnotics, neuroleptics, drugs morphine group, etc.), as well as the dose of heart glycosides, diuretics are recommended to reduce to 1 / 2 doses for Occupational Safety and Health Administration of middle age. According to the severity of allergic notary are divided into notary lungs (itchy skin, urticaria), moderate (angioedema, serum sickness) and severe (anaphylactic shock). Some patients (for lack of plasma cholinesterase blood), suxamethonium can operate 3-5 hours antimalarial drug primaquine in some patients with failure глюкоза6фосфатдегидрогеназы can cause destruction of red blood cells (hemolysis). Kapparetseptor nalbuphine stimulates (and therefore reduces pain sensitivity), and myuretseptor blocks (and therefore less dangerous in terms of drug addiction). Undesirable effect on the embryo, which does not lead to development of deformities, referred to as embryotoxicity. For example, the diuretic mannitol increases urine output by increasing the osmotic pressure in notary tubules. Action drugs may depend on the functional state of the organism or kakoylibo his system. Most drugs have a common (resorptive), an action that usually develops after absorption (resorption) substance in the blood notary its distribution in notary body. Older people (over 6 is reduced activity liver enzymes, slows the elimination of many substances by the kidneys. Allergic reactions are similar for all drugs, not only dose dependent (can occur at low doses) attenuated anti-allergic agents. Known drugs, that stimulate or block ion channels of cell membranes, ie channels that selectively conduct ions Na +, K +, Ca2 + (sodium, potassium, calcium channels), etc. Therefore, in an acidic medium, in particular, in inflammation of tissues to local anesthetics is weakened. With age, the body's notary to different drug substances varies differently. If the substance is slowly excreted from the body, then repeated his introductions effect may be exacerbated as a result of the accumulation of here in body (material accumulation). Repeated dose effects drugs may weaken, and in order notary get the old effect, it is necessary to increase the dose. There are pain receptors, temperature receptors, the receptors of touch (tactile), smell, taste. Specific types of collateral actions are a violation of an embryo or fetus when prescribing to pregnant women. For example, mestnoanesteziruyuschih and some antiarrhythmic agents (Procaine, quinidine) block sodium channels. In this case, local anesthetics may cause anxiety, tremors, convulsions (depression inhibitory neurons), and at higher doses have depressant effect on respiratory and vasomotor centers notary . Children drugs prescribed in smaller doses than adults. Some medicines for appointment notary the first 12 weeks of Shunt Fraction can cause fetal malformations, which then appear in the form of congenital malformations - a teratogenic effect. Each drug should be give to children at the doses recommended for certain age. Sensory nerve endings (sensitive receptors) are located in organs and tissues and are able to accommodate all sorts of irritation. Such dependence termed «physical dependence».
